Platelet Function Assay Implementation & Validation Services

Specialist Expertise for Reliable, Reproducible Platelet Function Testing

Implementing platelet function testing within a clinical laboratory requires careful consideration of pre-analytical variables, assay methodology, sample requirements, analytical performance, clinical application and quality management.

We provide specialist support to laboratories, healthcare organisations and IVD manufacturers in the selection, implementation, verification and validation of platelet function assays.

From initial assay evaluation through to routine clinical service, we provide a structured, practical and evidence-based approach designed to ensure that platelet function testing is fit for its intended clinical purpose.

SPECIALIST CLINICAL APPLICATIONS

Our implementation expertise can support laboratories developing services for:

- Inherited platelet function disorders

- Acquired platelet dysfunction

- Bleeding disorders

- Antiplatelet therapy monitoring

- Pre-operative platelet assessment

- Unexplained bleeding

- Specialist haemostasis investigations

- Research and clinical trials

- Specialist thrombosis and haemostasis services

Don't let assay validation become the bottleneck.

Whether you are:

Introducing a new platelet function service,

Changing analyser or methodology,

Implementing a new platelet assay

Developing an LDT,

We provide specialist support throughout the implementation and validation pathway.

Find out more

PLATELET FUNCTION ASSAYS WE SUPPORT

Light Transmission Aggregometry — LTA

Support for traditional and specialist platelet aggregation testing using agonists such as:

- ADP

- Collagen

- Epinephrine

- Arachidonic acid

- Ristocetin

- Other specialist agonists where appropriate

Validation considerations can include aggregation response, reproducibility, agonist concentrations, reference ranges and interpretation of abnormal patterns.

Impedance Aggregometry

Support for whole-blood platelet function testing, including evaluation of:

- Precision

- Reproducibility

- Agonist response

- Sample stability

- Reference intervals

- Method comparison

- QC performance

Platelet Flow Cytometry

Support for implementation of platelet flow cytometric assays, including:

- Platelet identification

- Activation markers

- Receptor expression

- Platelet glycoprotein assessment

- Activation studies

- Control strategies

- Analytical performance

Microfluidic & Flow-Based Platelet Assays

Specialist support for emerging platelet function methodologies, including whole-blood flow chamber and microfluidic approaches.

Validation considerations can include:

- Flow conditions

- Surface preparation

- Shear conditions

- Platelet adhesion

- Platelet aggregation

- Thrombus formation

- Image analysis

- Positive and negative controls

- Assay reproducibility

Point-of-Care Platelet Function Testing

Assessment of aspirin and clopidogrel response and is suitable for the routine investigation of antiplatelet therapy effectiveness and suspected antiplatelet resistance